In the United States and throughout the world, health care is undergoing a transformation. It is a reaction to the broad recognition that the current system — such as it is — is unsustainable. The clear solution is to increase the value of care: improving patient outcomes while containing, if not reducing, costs. Breakthroughs, especially in genomics, promise to deepen understanding of diseases and ways to combat them. But all stakeholders — governments, consumers, insurers, employers and providers themselves — realize that scientific advances alone will not suffice. To produce the best health outcomes at the lowest cost, virtually every aspect of the delivery system must be revamped — from leadership, organizational structures and culture, and processes, to teamwork, and incentives.