Many health care organizations today are striving to deliver better patient outcomes at lower cost and to be rewarded for accomplishing both. Most have begun this journey with pilot projects to obtain valid measures of outcomes and cost for one or two medical conditions. They implement process improvement and standardize care pathways from a patient’s initial office visit through all aspects of treating the condition, and then explore offering new value-based payment models, including bundled payments, for those conditions. To accelerate the dissemination and adoption of this value agenda for many more medical conditions, leaders should now consider establishing a new central office to oversee the creation of all the capabilities and information for such initiatives.