The U.S. supply chain is generally recognized as an integral part of the American economy. From Intel’s semiconductors to Microsoft’s enterprise software, the supply chain builds the goods and services that businesses need. But for all of its importance, no one has identified what industries comprise the U.S. supply chain economy, quantified the number and quality of jobs it contains, or assessed how much it matters for innovation. We attempted to answer these questions by creating a novel categorization of the U.S. economy that reveals new ways to drive American growth and innovation.