Providing health care in rural regions presents unique challenges. For some patients, the closest doctor may be a three-hour drive. Clinicians seeking an expert consult may find there’s no appropriate specialist within 100 miles. And vast distance can hinder the dissemination of best practices and coordination of care. At Sanford Health, one of the largest rural health-care-delivery systems, we’ve tackled this challenge by leveraging an array of technologies to provide high-value care to a population of around 2 million, dispersed across 300,000 square miles in the Dakotas. We’ve adopted a single electronic medical record (EMR) platform, embraced telehealth technologies, developed enterprise-wide departments, and committed to data transparency.