Harvard Business Review

SEPTEMBER 12, 2012

Since companies test their own products—an obvious conflict of interest—they naturally design clinical trials to maximize evidence that they are beneficial and minimize evidence they are harmful. Safra Center for Ethics , some fellows study how these institutional practices corrupt medical science and clinical practice.

Business Model 15

Business Model Company Pharmaceuticals Price 15

Harvard Business Review

DECEMBER 6, 2012

For example, the SEC in 2010 had charged Goldman with misleading some of the parties to a billion dollar transaction (involving a complex derivative called a synthetic collateralized debt obligation), alleging specific facts about undisclosed conflicts of interest. Goldman settled within months for $550 million.

Conflict of Interest 8

Conflict of Interest CEO Asset Management Committee 8

Harvard Business Review

FEBRUARY 3, 2017

The estimated return on these (fewer) products has itself declined substantially since 2010, from 10.1% For instance, 60 institutional investors, collectively managing more than $5.5 For each $1 billion spent on R&D, the number of new medicines approved has halved roughly every nine years since 1950. Enhance corporate reputations.

Reputation 8

Reputation Pharmaceuticals Price Business Model 8