For most people in health care, being involved in designing a new hospital is a once-in-a-lifetime opportunity to transform both their work environment and the care they deliver. We at University of Texas Southwestern Medical Center certainly feel that way about our William P. Clements Jr. University Hospital, which opened in December 2014. For its significant improvements in quality and accountability, our hospital received the Rising Star Award from the University HealthSystem Consortium. We attribute much of our success to making patients and frontline health care professionals the true architects of the project. I’d like to share the features of our innovative planning process, with an eye toward helping other institutions adopt the elements that will work for them.